Not4-dependent translation repression is important for cellular protein homeostasis in yeast

As you will see from the reports, all referees express interest in the findings reported in your manuscript, although they also raise a number of concerns that will have to be addressed in full before they can support publication. In particular, ref #1 (who also saw the earlier submission of this study) finds that the data supporting the model for translational repression as the main role for Not4 remain partially inconclusive and need to strengthened further. This point is reflected in the comments from ref #3 (new ref) who finds that the quantitative aspects of the work needs to be established better and that several reported observations appear at odds with the underlying model. I realize that ref #2 (also new ref) is the most positive of the three, but given the nature of the concerns raised by the other refs (especially concerning the conclusiveness of the data) the points raised by ref#1 and #3 will need to be addressed in full.